AIM2 Antibody (PACO06240)
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주문- SKU:
- PACO06240
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | AIM2 Antibody (PACO06240) |
Antibody SKU: | PACO06240 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from the Internal region of human AIM2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of HuvEc cells using AIM2 Polyclonal Antibody. | |
Western Blot analysis of HuvEc cells using AIM2 Polyclonal Antibody. |
Synonyms: | AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2 |
UniProt Protein Function: | AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 1q22 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; protein binding; double-stranded DNA binding Biological Process: positive regulation of interleukin-1 beta production; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; immune response; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor |
NCBI Summary: | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14862 |
NCBI GenInfo Identifier: | 5902751 |
NCBI Gene ID: | 9447 |
NCBI Accession: | O14862.1 |
UniProt Secondary Accession: | O14862,Q5T3V9, Q96FG9, A8K7M7, |
UniProt Related Accession: | O14862 |
Molecular Weight: | 343 |
NCBI Full Name: | Interferon-inducible protein AIM2 |
NCBI Synonym Full Names: | absent in melanoma 2 |
NCBI Official Symbol: | AIM2 |
NCBI Official Synonym Symbols: | PYHIN4 |
NCBI Protein Information: | interferon-inducible protein AIM2 |
UniProt Protein Name: | Interferon-inducible protein AIM2 |
UniProt Synonym Protein Names: | Absent in melanoma 2 |
Protein Family: | Protein |
UniProt Gene Name: | AIM2 |
UniProt Entry Name: | AIM2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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