AGFG1 Antibody (PACO15346)
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주문- SKU:
- PACO15346
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AGFG1 Antibody (PACO15346) |
Antibody SKU: | PACO15346 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human AGFG1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, Hela cells, 293T cells, K562 cells, human testis tissue, Primary antibody: PACO15346(AGFG1 Antibody) at dilution 1/727, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO15346(AGFG1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | ArfGAP with FG repeats 1 |
UniProt Protein Function: | RIP: Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. Interacts with EPS15R and EPS15. Interacts with FCHO1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear export; RNA-binding Chromosomal Location of Human Ortholog: 2q36.3 Cellular Component: intracellular membrane-bound organelle; nuclear pore Molecular Function:protein binding; RNA binding Biological Process: mRNA export from nucleus |
NCBI Summary: | The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
UniProt Code: | P52594 |
NCBI GenInfo Identifier: | 26007019 |
NCBI Gene ID: | 3267 |
NCBI Accession: | P52594.2 |
UniProt Secondary Accession: | P52594,Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11 B3KUL1, E9PHX7, |
UniProt Related Accession: | P52594 |
Molecular Weight: | 60,767 Da |
NCBI Full Name: | Arf-GAP domain and FG repeat-containing protein 1 |
NCBI Synonym Full Names: | ArfGAP with FG repeats 1 |
NCBI Official Symbol: | AGFG1 |
NCBI Official Synonym Symbols: | HRB; RAB; RIP |
NCBI Protein Information: | arf-GAP domain and FG repeat-containing protein 1 |
UniProt Protein Name: | Arf-GAP domain and FG repeat-containing protein 1 |
UniProt Synonym Protein Names: | HIV-1 Rev-binding protein; Nucleoporin-like protein RIP; Rev-interacting protein; Rev/Rex activation domain-binding protein |
Protein Family: | Riparin |
UniProt Gene Name: | AGFG1 |