AEBP1 Antibody (PACO18648)
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주문- SKU:
- PACO18648
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AEBP1 Antibody (PACO18648) |
Antibody SKU: | PACO18648 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human AEBP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18648(AEBP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18648(AEBP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. |
Synonyms: | AE binding protein 1 |
UniProt Protein Function: | AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p13 Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus Molecular Function:calmodulin binding; carboxypeptidase activity; zinc ion binding; transcription factor activity; metallocarboxypeptidase activity; transcription corepressor activity Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development |
NCBI Summary: | This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013] |
UniProt Code: | Q8IUX7 |
NCBI GenInfo Identifier: | 119581523 |
NCBI Gene ID: | 165 |
NCBI Accession: | EAW61119.1 |
UniProt Secondary Accession: | Q8IUX7,Q14113, Q59ER7, Q6ZSC7, Q7KZ79, |
UniProt Related Accession: | Q8IUX7 |
Molecular Weight: | 82,183 Da |
NCBI Full Name: | AE binding protein 1 |
NCBI Synonym Full Names: | AE binding protein 1 |
NCBI Official Symbol: | AEBP1 |
NCBI Official Synonym Symbols: | ACLP |
NCBI Protein Information: | adipocyte enhancer-binding protein 1 |
UniProt Protein Name: | Adipocyte enhancer-binding protein 1 |
UniProt Synonym Protein Names: | Aortic carboxypeptidase-like protein |
Protein Family: | Adipocyte enhancer-binding protein |
UniProt Gene Name: | AEBP1 |
UniProt Entry Name: | AEBP1_HUMAN |
Antibodies | ELISA Kits |
Anti-AEBP1 Antibody (CAB16340) | Human Adipocyte enhancer-binding protein 1 (AEBP1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |