ADNP Antibody (PACO19316)
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주문- SKU:
- PACO19316
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADNP Antibody (PACO19316) |
Antibody SKU: | PACO19316 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human ADNP |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19316(ADNP Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19316(ADNP Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. |
Synonyms: | activity-dependent neuroprotector homeobox |
UniProt Protein Function: | ADNP: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Apoptosis Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: extracellular space; nucleus Molecular Function:protein binding; DNA binding; metal ion binding; chromatin binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of neuron apoptosis Disease: Mental Retardation, Autosomal Dominant 28 |
NCBI Summary: | Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H2P0 |
NCBI GenInfo Identifier: | 24636245 |
NCBI Gene ID: | 23394 |
NCBI Accession: | Q9H2P0.1 |
UniProt Secondary Accession: | Q9H2P0,O94881, Q5BKU2, Q9UG34, E1P5Y2, |
UniProt Related Accession: | Q9H2P0 |
Molecular Weight: | 1102 |
NCBI Full Name: | Activity-dependent neuroprotector homeobox protein |
NCBI Synonym Full Names: | activity-dependent neuroprotector homeobox |
NCBI Official Symbol: | ADNP |
NCBI Official Synonym Symbols: | ADNP1; MRD28 |
NCBI Protein Information: | activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; activity-dependent neuroprotective protein |
UniProt Protein Name: | Activity-dependent neuroprotector homeobox protein |
UniProt Synonym Protein Names: | Activity-dependent neuroprotective protein |
Protein Family: | ADNP homeobox protein |
UniProt Gene Name: | ADNP |
UniProt Entry Name: | ADNP_HUMAN |