ADM Antibody (PACO19271)
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주문- SKU:
- PACO19271
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADM Antibody (PACO19271) |
Antibody SKU: | PACO19271 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthetic peptide of human ADM |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19271(ADM Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acid, , has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acid, long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. |
Synonyms: | adrenomedullin |
UniProt Protein Function: | ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytoplasm; extracellular region; extracellular space Molecular Function:protein binding; receptor binding Biological Process: antibacterial humoral response; antifungal humoral response; blood circulation; cAMP biosynthetic process; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; G-protein coupled receptor internalization; negative regulation of vasoconstriction; positive regulation of cAMP biosynthetic process; progesterone biosynthetic process; receptor internalization; response to yeast; signal transduction; vasculogenesis |
NCBI Summary: | The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014] |
UniProt Code: | P35318 |
NCBI GenInfo Identifier: | 461474 |
NCBI Gene ID: | 133 |
NCBI Accession: | P35318.1 |
UniProt Secondary Accession: | P35318,Q6FGW2, B2R793, D3DQV3, |
UniProt Related Accession: | P35318 |
Molecular Weight: | 20,420 Da |
NCBI Full Name: | ADM |
NCBI Synonym Full Names: | adrenomedullin |
NCBI Official Symbol: | ADM |
NCBI Official Synonym Symbols: | AM; PAMP |
NCBI Protein Information: | ADM |
UniProt Protein Name: | ADM |
UniProt Synonym Protein Names: | Adrenomedullin; AM |
Protein Family: | ADM |
UniProt Gene Name: | ADM |
UniProt Entry Name: | ADML_HUMAN |
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