ADGRB1 Antibody (PACO45411)
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주문- SKU:
- PACO45411
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADGRB1 Antibody (PACO45411) |
Antibody SKU: | PACO45411 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Adhesion G protein-coupled receptor B1 protein (60-350AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO45411 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human glioma using PACO45411 at dilution of 1:100. |
Background: | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. |
Synonyms: | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)], ADGRB1, BAI1 |
UniProt Protein Function: | BAI1: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 8q24.3Cellular Component: integral to membrane; integral to plasma membrane; intercellular junction; plasma membrane; postsynaptic densityMolecular Function: G-protein coupled receptor activityBiological Process: axonogenesis; cell adhesion; cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; peripheral nervous system development; positive regulation of synaptogenesis; signal transduction |
UniProt Protein Details: | |
NCBI Summary: | Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008] |
UniProt Code: | O14514 |
NCBI GenInfo Identifier: | 410516865 |
NCBI Gene ID: | 575 |
NCBI Accession: | O14514.2 |
UniProt Secondary Accession: | O14514,Q3UHD1 |
UniProt Related Accession: | O14514 |
Molecular Weight: | 173,501 Da |
NCBI Full Name: | Brain-specific angiogenesis inhibitor 1 |
NCBI Synonym Full Names: | adhesion G protein-coupled receptor B1 |
NCBI Official Symbol: | ADGRB1 |
NCBI Official Synonym Symbols: | BAI1; GDAIF |
NCBI Protein Information: | brain-specific angiogenesis inhibitor 1 |
UniProt Protein Name: | Brain-specific angiogenesis inhibitor 1 |
UniProt Synonym Protein Names: | |
Protein Family: | BAI1-associated protein |
UniProt Gene Name: | BAI1 |
UniProt Entry Name: | BAI1_HUMAN |