ADAR Antibody (PACO18518)
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주문- SKU:
- PACO18518
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ADAR Antibody (PACO18518) |
Antibody SKU: | PACO18518 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:3000-1:10000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ADAR |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18518(ADAR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18518(ADAR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. |
Synonyms: | adenosine deaminase, RNA-specific |
UniProt Protein Function: | ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter. |
UniProt Protein Details: | Protein type:EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus Molecular Function:double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; metal ion binding Biological Process: positive regulation of viral genome replication; base conversion or substitution editing; in utero embryonic development; response to virus; cytokine and chemokine mediated signaling pathway; miRNA-mediated gene silencing, miRNA loading onto RISC; somatic diversification of immune receptors via somatic mutation; adenosine to inosine editing; osteoblast differentiation; negative regulation of viral genome replication; pre-microRNA processing; protein import into nucleus; mRNA modification; erythrocyte differentiation; innate immune response; hemopoietic progenitor cell differentiation; gene expression; protein export from nucleus; mRNA processing; defense response to virus; negative regulation of apoptosis Disease: Dyschromatosis Symmetrica Hereditaria; Aicardi-goutieres Syndrome 6 |
NCBI Summary: | This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] |
UniProt Code: | P55265 |
NCBI GenInfo Identifier: | 70167113 |
NCBI Gene ID: | 103 |
NCBI Accession: | NP_001020278.1 |
UniProt Secondary Accession: | P55265,O15223, O43859, O43860, Q9BYM3, Q9BYM4, B1AQQ9 B1AQR0, D3DV76, |
UniProt Related Accession: | P55265 |
Molecular Weight: | |
NCBI Full Name: | double-stranded RNA-specific adenosine deaminase isoform d |
NCBI Synonym Full Names: | adenosine deaminase, RNA-specific |
NCBI Official Symbol: | ADAR |
NCBI Official Synonym Symbols: | DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP |
NCBI Protein Information: | double-stranded RNA-specific adenosine deaminase |
UniProt Protein Name: | Double-stranded RNA-specific adenosine deaminase |
UniProt Synonym Protein Names: | 136 kDa double-stranded RNA-binding protein; p136; Interferon-inducible protein 4; IFI-4; K88DSRBP |
Protein Family: | Double-stranded RNA-specific editase |
UniProt Gene Name: | ADAR |
UniProt Entry Name: | DSRAD_HUMAN |