UniProt Protein Function: | ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region Molecular Function:integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification |
NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q9UNA0 |
NCBI GenInfo Identifier: | 317373326 |
NCBI Gene ID: | 11096 |
NCBI Accession: | Q9UNA0.2 |
UniProt Related Accession: | Q9UNA0 |
Molecular Weight: | |
NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
NCBI Official Symbol: | ADAMTS5 |
NCBI Official Synonym Symbols: | ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11 |
NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
UniProt Synonym Protein Names: | A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2 |
UniProt Gene Name: | ADAMTS5 |
UniProt Entry Name: | ATS5_HUMAN |