ADAM11 Antibody (PACO19051)
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주문- SKU:
- PACO19051
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADAM11 Antibody (PACO19051) |
Antibody SKU: | PACO19051 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human ADAM11 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19051(ADAM11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Hela cells, SKOV3 cells, Primary antibody: PACO19051(ADAM11 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19051(ADAM11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. |
Synonyms: | ADAM metallopeptidase domain 11 |
UniProt Protein Function: | ADAM11: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: extracellular matrix; plasma membrane Molecular Function:integrin binding; metallopeptidase activity Biological Process: integrin-mediated signaling pathway |
NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | O75078 |
NCBI GenInfo Identifier: | 115502351 |
NCBI Gene ID: | 4185 |
NCBI Accession: | O75078.3 |
UniProt Secondary Accession: | O75078,Q14808, Q14809, Q14810, |
UniProt Related Accession: | O75078,AAB29191 |
Molecular Weight: | 57,911 Da |
NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 11 |
NCBI Synonym Full Names: | ADAM metallopeptidase domain 11 |
NCBI Official Symbol: | ADAM11 |
NCBI Official Synonym Symbols: | MDC |
NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 11 |
UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 11 |
UniProt Synonym Protein Names: | Metalloproteinase-like, disintegrin-like, and cysteine-rich protein; MDC |
Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
UniProt Gene Name: | ADAM11 |
UniProt Entry Name: | ADA11_HUMAN |
Antibodies |
Anti-ADAM11 Antibody (CAB14249) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |