ACVR2B Antibody (PACO14112)
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주문- SKU:
- PACO14112
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ACVR2B Antibody (PACO14112) |
Antibody SKU: | PACO14112 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ACVR2B |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14112(ACVR2B Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO14112(ACVR2B Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14112(ACVR2B Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-β (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
Synonyms: | activin A receptor, type IIB |
UniProt Protein Function: | ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; TKL group; STKR family; Type2 subfamily Chromosomal Location of Human Ortholog: 3p22 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex Molecular Function:transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; growth factor binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; activin binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; pancreas development; transmembrane receptor protein serine/threonine kinase signaling pathway; lymphangiogenesis; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development Disease: Heterotaxy, Visceral, 4, Autosomal |
NCBI Summary: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13705 |
NCBI GenInfo Identifier: | 97535735 |
NCBI Gene ID: | 93 |
NCBI Accession: | Q13705.3 |
UniProt Secondary Accession: | Q13705,Q4VAV0, |
UniProt Related Accession: | Q13705 |
Molecular Weight: | – Da |
NCBI Full Name: | Activin receptor type-2B |
NCBI Synonym Full Names: | activin A receptor, type IIB |
NCBI Official Symbol: | ACVR2B |
NCBI Official Synonym Symbols: | HTX4; ACTRIIB; ActR-IIB |
NCBI Protein Information: | activin receptor type-2B |
UniProt Protein Name: | Activin receptor type-2B |
UniProt Synonym Protein Names: | Activin receptor type IIB; ACTR-IIB |
Protein Family: | Activin receptor |
UniProt Gene Name: | ACVR2B |
UniProt Entry Name: | AVR2B_HUMAN |
Antibodies |
Anti-ACVR2B Antibody (CAB7868) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |