ACTR2 Antibody (PACO42974)
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주문- SKU:
- PACO42974
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ACTR2 Antibody (PACO42974) |
Antibody SKU: | PACO42974 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Actin-related protein 2 protein (1-160AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO42974 at dilution of 1:100. |
Background: | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. |
Synonyms: | Actin-related protein 2 (Actin-like protein 2), ACTR2, ARP2 |
UniProt Protein Function: | ARP2: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the actin family. ARP2 subfamily. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal Chromosomal Location of Human Ortholog: 2p14 Cellular Component: Arp2/3 protein complex; focal adhesion; cell projection; membrane; cytoplasm; cytosol; actin cap; actin cytoskeleton Molecular Function:actin filament binding; structural constituent of cytoskeleton; ATP binding Biological Process: axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; ephrin receptor signaling pathway; establishment and/or maintenance of cell polarity; innate immune response; cilium biogenesis; cytokinesis after meiosis; cell motility; cytoplasmic transport; spindle localization |
NCBI Summary: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61160 |
NCBI GenInfo Identifier: | 47117648 |
NCBI Gene ID: | 10097 |
NCBI Accession: | P61160.1 |
UniProt Secondary Accession: | P61160,O15142, Q96C82, B2RCP5, D6W5F4, E9PF41, |
UniProt Related Accession: | P61160 |
Molecular Weight: | 394 |
NCBI Full Name: | Actin-related protein 2 |
NCBI Synonym Full Names: | ARP2 actin-related protein 2 homolog (yeast) |
NCBI Official Symbol: | ACTR2 |
NCBI Official Synonym Symbols: | ARP2 |
NCBI Protein Information: | actin-related protein 2; actin-like protein 2 |
UniProt Protein Name: | Actin-related protein 2 |
UniProt Synonym Protein Names: | Actin-like protein 2 |
UniProt Gene Name: | ACTR2 |
UniProt Entry Name: | ARP2_HUMAN |