ACSL4 Antibody (PACO15618)
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주문- SKU:
- PACO15618
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ACSL4 Antibody (PACO15618) |
Antibody SKU: | PACO15618 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ACSL4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2 cells, hela cells, 293T cells, human fetal kidney tissue, Primary antibody: PACO15618(ACSL4 Antibody) at dilution 1/225, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15618(ACSL4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is an isozyme of the long-chain fatty-acid, coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acid, into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid, degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. |
Synonyms: | acyl-CoA synthetase long-chain family member 4 |
UniProt Protein Function: | ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 6.2.1.3; Ligase Chromosomal Location of Human Ortholog: Xq22.3-q23 Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane Molecular Function:arachidonate-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity Biological Process: lipid metabolic process Disease: Mental Retardation, X-linked 63 |
NCBI Summary: | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016] |
UniProt Code: | O60488 |
NCBI GenInfo Identifier: | 13432172 |
NCBI Gene ID: | 2182 |
NCBI Accession: | O60488.2 |
UniProt Secondary Accession: | O60488,O60848, O60849, Q5JWV8, D3DUY2, |
UniProt Related Accession: | O60488 |
Molecular Weight: | 74,436 Da |
NCBI Full Name: | Long-chain-fatty-acid--CoA ligase 4 |
NCBI Synonym Full Names: | acyl-CoA synthetase long-chain family member 4 |
NCBI Official Symbol: | ACSL4 |
NCBI Official Synonym Symbols: | ACS4; FACL4; LACS4; MRX63; MRX68 |
NCBI Protein Information: | long-chain-fatty-acid--CoA ligase 4 |
UniProt Protein Name: | Long-chain-fatty-acid--CoA ligase 4 |
UniProt Synonym Protein Names: | Long-chain acyl-CoA synthetase 4; LACS 4 |
UniProt Gene Name: | ACSL4 |
UniProt Entry Name: | ACSL4_HUMAN |