ACR Antibody (PACO19049)
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주문- SKU:
- PACO19049
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ACR Antibody (PACO19049) |
Antibody SKU: | PACO19049 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ACR |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: A549 cells, Primary antibody: PACO19049(ACR Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19049(ACR Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. |
Synonyms: | Acrosin |
UniProt Protein Function: | ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family. |
UniProt Protein Details: | Protein type:EC 3.4.21.10; Protease Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: acrosomal matrix; extracellular region; nucleus; protein complex Molecular Function:amidase activity; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity Biological Process: acrosome reaction; adenylate cyclase activation; penetration of zona pellucida; single fertilization |
NCBI Summary: | Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008] |
UniProt Code: | P10323 |
NCBI GenInfo Identifier: | 115502349 |
NCBI Gene ID: | 49 |
NCBI Accession: | P10323.4 |
UniProt Secondary Accession: | P10323,Q6ICK2, |
UniProt Related Accession: | P10323 |
Molecular Weight: | 45,847 Da |
NCBI Full Name: | Acrosin |
NCBI Synonym Full Names: | acrosin |
NCBI Official Symbol: | ACR |
NCBI Protein Information: | acrosin |
UniProt Protein Name: | Acrosin |
Protein Family: | Acrosin |
UniProt Gene Name: | ACR |
UniProt Entry Name: | ACRO_HUMAN |
Antibodies | ELISA Kits |
Anti-ACR Antibody (CAB18631) | Human Acrosin ELISA Kit |
ACR Antibody (PACO00001) | Human Acrosin (ACR) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |