ABL2 Antibody (PACO02046)
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주문- SKU:
- PACO02046
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ABL2 Antibody |
Antibody SKU: | PACO02046 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Arg. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG |
UniProt Protein Function: | Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Oncoprotein; TK group; Abl family Chromosomal Location of Human Ortholog: 1q25.2 Cellular Component: actin cytoskeleton; cytosol; extrinsic to internal side of plasma membrane Molecular Function:actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine phosphorylation; positive regulation of oxidoreductase activity; protein modification process; regulation of autophagy; regulation of cell adhesion; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
UniProt Code: | P42684 |
NCBI GenInfo Identifier: | 1168268 |
NCBI Gene ID: | 27 |
NCBI Accession: | P42684.1 |
UniProt Secondary Accession: | P42684,Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301, A0M8X0, B7UEF2 B7UEF3, B7UEF4, B7UEF5, |
UniProt Related Accession: | P42684 |
Molecular Weight: | 60,864 Da |
NCBI Full Name: | Abelson tyrosine-protein kinase 2 |
NCBI Synonym Full Names: | ABL proto-oncogene 2, non-receptor tyrosine kinase |
NCBI Official Symbol: | ABL2 |
NCBI Official Synonym Symbols: | ARG; ABLL |
NCBI Protein Information: | Abelson tyrosine-protein kinase 2 |
UniProt Protein Name: | Abelson tyrosine-protein kinase 2 |
UniProt Synonym Protein Names: | Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG |
Protein Family: | Abelson tyrosine-protein kinase |
UniProt Gene Name: | ABL2 |
UniProt Entry Name: | ABL2_HUMAN |