ABCC5 Antibody (PACO18222)
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주문- SKU:
- PACO18222
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ABCC5 Antibody (PACO18222) |
Antibody SKU: | PACO18222 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human ABCC5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18222(ABCC5 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO18222(ABCC5 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18222(ABCC5 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. |
Synonyms: | ATP-binding cassette, sub-family C |
UniProt Protein Function: | ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity Biological Process: hyaluronan biosynthetic process; transmembrane transport; transport |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
UniProt Code: | O15440 |
NCBI GenInfo Identifier: | 8928547 |
NCBI Gene ID: | 10057 |
NCBI Accession: | O15440.2 |
UniProt Secondary Accession: | O15440,O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85 Q9UNP5, Q9UQC3, B9EIQ2, |
UniProt Related Accession: | O15440 |
Molecular Weight: | 161kDa |
NCBI Full Name: | Multidrug resistance-associated protein 5 |
NCBI Synonym Full Names: | ATP binding cassette subfamily C member 5 |
NCBI Official Symbol: | ABCC5 |
NCBI Official Synonym Symbols: | MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145 |
NCBI Protein Information: | multidrug resistance-associated protein 5 |
UniProt Protein Name: | Multidrug resistance-associated protein 5 |
UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11 |
Protein Family: | ABC transporter C family |
UniProt Gene Name: | ABCC5 |
Antibodies | ELISA Kits |
Anti-ABCC5 Antibody (CAB11978) | Human ABCC5 / ATP Binding Cassette Transporter C5 ELISA Kit |
Anti-ABCC5 Antibody (CAB3028) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |