UniProt Protein Function: | ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Hydrolase; Transporter, ABC family; Membrane protein, integral; Mitochondrial; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q36 Cellular Component: mitochondrial envelope; mitochondrion; membrane; mitochondrial inner membrane; integral to membrane; nucleolus; ATP-binding cassette (ABC) transporter complex; nucleus Molecular Function:transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding Biological Process: transport; metabolic process; transmembrane transport |
NCBI Summary: | This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9NUT2 |
NCBI GenInfo Identifier: | 143811358 |
NCBI Gene ID: | 11194 |
NCBI Accession: | Q9NUT2.3 |
UniProt Related Accession: | Q9NUT2 |
Molecular Weight: | 80kDa |
NCBI Full Name: | ATP-binding cassette sub-family B member 8, mitochondrial |
NCBI Synonym Full Names: | ATP binding cassette subfamily B member 8 |
NCBI Official Symbol: | ABCB8 |
NCBI Official Synonym Symbols: | MABC1; M-ABC1; EST328128 |
NCBI Protein Information: | ATP-binding cassette sub-family B member 8, mitochondrial |
UniProt Protein Name: | ATP-binding cassette sub-family B member 8, mitochondrial |
UniProt Synonym Protein Names: | Mitochondrial ATP-binding cassette 1; M-ABC1 |
Protein Family: | ATP-binding cassette sub-family |
UniProt Gene Name: | ABCB8 |
UniProt Entry Name: | ABCB8_HUMAN |