UniProt Protein Function: | ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, ABC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:ATP binding; ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cell differentiation; compound eye corneal lens development; metabolic process; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; regulation of membrane potential; transmembrane transport |
NCBI Summary: | ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q2M3G0 |
NCBI GenInfo Identifier: | 693586060 |
NCBI Gene ID: | 340273 |
NCBI Accession: | Q2M3G0.4 |
UniProt Secondary Accession: | Q2M3G0,Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, A4D131, A7BKA4 B5MD19, B7WPL1, F8QQP8, F8QQP9, J3KQ04, |
UniProt Related Accession: | Q2M3G0 |
Molecular Weight: | 89,832 Da |
NCBI Full Name: | ATP-binding cassette sub-family B member 5 |
NCBI Synonym Full Names: | ATP binding cassette subfamily B member 5 |
NCBI Official Symbol: | ABCB5 |
NCBI Official Synonym Symbols: | ABCB5beta; EST422562; ABCB5alpha |
NCBI Protein Information: | ATP-binding cassette sub-family B member 5 |
UniProt Protein Name: | ATP-binding cassette sub-family B member 5 |
UniProt Synonym Protein Names: | ABCB5 P-gp; P-glycoprotein ABCB5 |
Protein Family: | ABC transporter B family |
UniProt Gene Name: | ABCB5 |
UniProt Entry Name: | ABCB5_HUMAN |