AAAS Antibody (PACO15334)
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주문- SKU:
- PACO15334
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | AAAS Antibody (PACO15334) |
Antibody SKU: | PACO15334 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human AAAS |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15334(AAAS Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15334(AAAS Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | achalasia, adrenocortical insufficiency, alacrimia |
UniProt Protein Function: | AAAS: Plays a role in the normal development of the peripheral and central nervous system. Defects in AAAS are the cause of achalasia-addisonianism- alacrima syndrome (AAAS); also known as triple-A syndrome or Allgrove syndrome. AAAS is an autosomal recessive disorder characterized by adreno-corticotropic hormone (ACTH)- resistant adrenal failure, achalasia of the esophageal cardia and alacrima. The syndrome is associated with variable and progressive neurological impairment involving the central, peripheral, and autonomic nervous system. Other features such as palmoplantar hyperkeratosis, short stature, facial dysmorphy and osteoporosis may also be present. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Nuclear envelope Chromosomal Location of Human Ortholog: 12q13 Cellular Component: nucleoplasm; centrosome; nuclear membrane; membrane; cytoplasm; nuclear pore; nuclear envelope; nucleus Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; nucleocytoplasmic transport; learning; viral infectious cycle; glucose transport; protein transport; fertilization; hexose transport; regulation of nucleocytoplasmic transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport Disease: Achalasia-addisonianism-alacrima Syndrome |
NCBI Summary: | The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q9NRG9 |
NCBI GenInfo Identifier: | 20137527 |
NCBI Gene ID: | 8086 |
NCBI Accession: | Q9NRG9.1 |
UniProt Related Accession: | Q9NRG9 |
Molecular Weight: | |
NCBI Full Name: | Aladin |
NCBI Synonym Full Names: | aladin WD repeat nucleoporin |
NCBI Official Symbol: | AAAS |
NCBI Official Synonym Symbols: | AAA; AAASb; GL003; ALADIN; ADRACALA; ADRACALIN |
NCBI Protein Information: | aladin |
UniProt Protein Name: | Aladin |
UniProt Synonym Protein Names: | Adracalin |
Protein Family: | Aladin |
UniProt Gene Name: | AAAS |
UniProt Entry Name: | AAAS_HUMAN |
Antibodies | ELISA Kits |
Anti-AAAS Antibody (CAB6427) | Human AAAS (Aladin) ELISA Kit (HUFI05487) |
AAAS Antibody (PACO01761) | |
AAAS Antibody (PACO07509) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |