Anti-ZFYVE1 Antibody (CAB7527)
- SKU:
- CAB7527
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ZFYVE1 Antibody |
| Antibody SKU: | CAB7527 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZFYVE1 (NP_067083.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZFYVE1 (NP_067083.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSAQ TSPA EKGL NPGL MCQE SYAC SGTD EAIF ECDE CCSL QCLR CEEE LHRQ ERLR NHER IRLK PGHV PYCD LCKG LSGH LPGV RQRA IVRC QTCK INLC LECQ KRTH SGGN KRRH PVTV YNVS NLQE SLEA EEMD EETK RKKM TEKV VSFL LVDE NEEI QVTN EEDF IRKL DCKP DQHL KVVS IFGN TGDG KSHT LNHT FFYG REVF KTSP TQES CTVG VWAA YDPV HKVA VIDT EGLL GATV NLSQ RTRL LLKV LAIS DLVI YRTH ADRL HNDL FKFL |
| Gene ID: | 53349 |
| Uniprot: | Q9HBF4 |
| Cellular Location: | Endoplasmic reticulum, Golgi apparatus, Golgi stack |
| Calculated MW: | 40kDa/85kDa/87kDa |
| Observed MW: | 87kDa |
| Synonyms: | ZFYVE1, DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1 |
| Background: | The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ZFYVE1: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q24.2 Cellular Component: autophagic vacuole; endoplasmic reticulum; Golgi stack; membrane; perinuclear region of cytoplasm Molecular Function:phosphatidylinositol binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding Biological Process: cellular response to starvation; macroautophagy |
| NCBI Summary: | The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9HBF4 |
| NCBI GenInfo Identifier: | 34098716 |
| NCBI Gene ID: | 53349 |
| NCBI Accession: | Q9HBF4.1 |
| UniProt Secondary Accession: | Q9HBF4,Q8WYX7, Q96K57, Q9BXP9, Q9HCI3, J3KNL9, |
| UniProt Related Accession: | Q9HBF4 |
| Molecular Weight: | 85,592 Da |
| NCBI Full Name: | Zinc finger FYVE domain-containing protein 1 |
| NCBI Synonym Full Names: | zinc finger FYVE-type containing 1 |
| NCBI Official Symbol: | ZFYVE1 |
| NCBI Official Synonym Symbols: | SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172 |
| NCBI Protein Information: | zinc finger FYVE domain-containing protein 1 |
| UniProt Protein Name: | Zinc finger FYVE domain-containing protein 1 |
| UniProt Synonym Protein Names: | Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1 |
| Protein Family: | Zinc finger FYVE domain-containing protein |
| UniProt Gene Name: | ZFYVE1 |
| UniProt Entry Name: | ZFYV1_HUMAN |
 | Western blot analysis of extracts of 293T cells, using ZFYVE1 antibody (CAB7527) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using ZFYVE1 antibody (CAB7527). Blue: DAPI for nuclear staining. |
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