Anti-SNX4 Antibody (CAB15342)
- SKU:
- CAB15342
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SNX4 Antibody |
| Antibody SKU: | CAB15342 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SNX4 (NP_003785.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-431, Mouse brain, Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SNX4 (NP_003785.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEQA PPDP ERQL QPAP LEPL GSPD AGLG AAVG KEAE GAGE ESSG VDTM THNN FWLK KIEI SVSE AEKR TGRN AMNM QETY TAYL IETR SVEH TDGQ SVLT DSLW RRYS EFEL LRSY LLVY YPHI VVPP LPEK RAEF VWHK LSAD NMDP DFVE RRRI GLEN FLLR IASH PILC RDKI FYLF LTQE GNWK ETVN ETGF QLKA DSRL KALN ATFR VKNP DKRF TDLK HYSD ELQS VISH LLRV RARV ADRL YG |
| Gene ID: | 8723 |
| Uniprot: | O95219 |
| Cellular Location: | Cytoplasmic side, Early endosome membrane, Peripheral membrane protein |
| Calculated MW: | 35kDa/51kDa |
| Observed MW: | 52kDa |
| Synonyms: | SNX4, ATG24B |
| Background: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. |
| UniProt Protein Function: | SNX4: May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q21.2 Cellular Component: cytoplasm; cytoplasmic dynein complex; early endosome membrane; extrinsic to membrane; membrane; plasma membrane; protein complex; SNARE complex Molecular Function:epidermal growth factor receptor binding; insulin receptor binding; phosphoinositide binding; protein binding Biological Process: endocytic recycling; endocytosis; protein transport; vesicle organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012] |
| UniProt Code: | O95219 |
| NCBI GenInfo Identifier: | 10720282 |
| NCBI Gene ID: | 8723 |
| NCBI Accession: | O95219.1 |
| UniProt Secondary Accession: | O95219,B3KMH0, B4DQV4, D3DNA3, |
| UniProt Related Accession: | O95219 |
| Molecular Weight: | 35,611 Da |
| NCBI Full Name: | Sorting nexin-4 |
| NCBI Synonym Full Names: | sorting nexin 4 |
| NCBI Official Symbol: | SNX4 |
| NCBI Official Synonym Symbols: | ATG24B |
| NCBI Protein Information: | sorting nexin-4 |
| UniProt Protein Name: | Sorting nexin-4 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX4 |
| UniProt Entry Name: | SNX4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX4 antibody (CAB15342) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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