Anti-SNCB Antibody (CAB10443)
- SKU:
- CAB10443
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SNCB Antibody |
| Antibody SKU: | CAB10443 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SNCB (NP_001001502.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse eye, Mouse brain, Rat brain, Rat spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SNCB (NP_001001502.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDVF MKGL SMAK EGVV AAAE KTKQ GVTE AAEK TKEG VLYV GSKT REGV VQGV ASVA EKTK EQAS HLGG AVFS GAGN IAAA TGLV KREE FPTD LKPE EVAQ EAAE EPLI EPLM EPEG ESYE DPPQ EEYQ EYEP EA |
| Gene ID: | 6620 |
| Uniprot: | Q16143 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 14kDa |
| Observed MW: | 16kDa |
| Synonyms: | SNCB |
| Background: | This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: inclusion body Molecular Function:calcium ion binding; phospholipase inhibitor activity; transition metal ion binding Disease: Dementia, Lewy Body |
| NCBI Summary: | This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q16143 |
| NCBI GenInfo Identifier: | 2501105 |
| NCBI Gene ID: | 6620 |
| NCBI Accession: | Q16143.1 |
| UniProt Secondary Accession: | Q16143,Q6IAX7, |
| UniProt Related Accession: | Q16143 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | Beta-synuclein |
| NCBI Synonym Full Names: | synuclein beta |
| NCBI Official Symbol: | SNCB |
| NCBI Protein Information: | beta-synuclein |
| UniProt Protein Name: | Beta-synuclein |
| Protein Family: | Beta-synuclein |
| UniProt Gene Name: | SNCB |
 | Western blot analysis of extracts of various cell lines, using SNCB antibody (CAB10443) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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