Anti-SLC25A11 Antibody (CAB8163)
- SKU:
- CAB8163
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | SLC25A11 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8163 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human SLC25A11 (NP_003553.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Raji, NCI-H460, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human SLC25A11 (NP_003553.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAT ASAG AGGI DGKP RTSP KSVK FLFG GLAG MGAT VFVQ PLDL VKNR MQLS GEGA KTRE YKTS FHAL TSIL KAEG LRGI YTGL SAGL LRQA TYTT TRLG IYTV LFER LTGA DGTP PGFL LKAV IGMT AGAT GAFV GTPA EVAL IRMT ADGR LPAD QRRG YKNV FNAL IRIT REEG VLTL WRGC IPTM ARAV VVNA AQLA SYSQ SKQF LLDS GYFS DNIL CHFC ASMI SGLV TTAA SMPV DIAK TRIQ NMRM IDGK PEYK NGLD VLFK VVRY EGFF SLWK GFTP YYAR LGPH TVLT FIFL EQMN KAYK RLFL SG |
| Gene ID: | 8402 |
| Uniprot: | Q02978 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 28kDa/34kDa |
| Observed MW: | 34kDa |
| Synonyms: | SLC25A11, OGC, SLC20A4 |
| Background: |
| UniProt Protein Function: | SLC25A11: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: integral to plasma membrane; mitochondrial inner membrane; mitochondrion; nucleus Molecular Function:oxoglutarate:malate antiporter activity Biological Process: gluconeogenesis; glucose metabolic process; transport |
| NCBI Summary: | The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q02978 |
| NCBI GenInfo Identifier: | 21361114 |
| NCBI Gene ID: | 8402 |
| NCBI Accession: | NP_003553.2 |
| UniProt Secondary Accession: | Q02978,O75537, Q969P7, F5GY65, |
| UniProt Related Accession: | Q02978 |
| Molecular Weight: | 37.8kDa |
| NCBI Full Name: | mitochondrial 2-oxoglutarate/malate carrier protein isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 25 member 11 |
| NCBI Official Symbol: | SLC25A11 |
| NCBI Official Synonym Symbols: | OGC; SLC20A4 |
| NCBI Protein Information: | mitochondrial 2-oxoglutarate/malate carrier protein |
| UniProt Protein Name: | Mitochondrial 2-oxoglutarate/malate carrier protein |
| UniProt Synonym Protein Names: | Solute carrier family 25 member 11 |
| UniProt Gene Name: | SLC25A11 |
 | Western blot analysis of extracts of various cell lines, using SLC25A11 antibody (CAB8163) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using SLC25A11 antibody (CAB8163) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using SLC25A11 antibody (CAB8163) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using SLC25A11 antibody (CAB8163) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using SLC25A11 antibody (CAB8163) at dilution of 1:100 (40x lens). |
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