Anti-SH3BP4 Antibody (CAB14351)
- SKU:
- CAB14351
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SH3BP4 Antibody |
| Antibody SKU: | CAB14351 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-963 of human SH3BP4 (NP_055336.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, BxPC-3, HepG2, Mouse thymus, Mouse brain, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-963 of human SH3BP4 (NP_055336.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TFFC RAEL DSEP ERVA SVLE KLKE DCNN TENK ERKS FQKE LVMA LLKM DCQG LVVR LIQD FVLL TTAV EVAQ RWRE LAEK LAKV SKQQ MDAY ESPH RDRN GVVD SEAM WKPA YDFL LTWS HQIG DSYR DVIQ ELHL GLDK MKNP ITKR WKHL TGTL ILVN SLDV LRAA AFSP ADQD DFVI |
| Gene ID: | 23677 |
| Uniprot: | Q9P0V3 |
| Cellular Location: | Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, clathrin-coated vesicle |
| Calculated MW: | 60kDa/107kDa |
| Observed MW: | 107kDa |
| Synonyms: | SH3BP4, BOG25, TTP |
| Background: | This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. |
| UniProt Protein Function: | SH3BP4: Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Vesicle Chromosomal Location of Human Ortholog: 2q37.1-q37.2 Cellular Component: cytoplasm Molecular Function:GDP-dissociation inhibitor activity; identical protein binding; protein binding; Ras GTPase binding Biological Process: amino acid import; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of TOR signaling pathway; positive regulation of autophagy; regulation of catalytic activity |
| NCBI Summary: | This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P0V3 |
| NCBI GenInfo Identifier: | 74753102 |
| NCBI Gene ID: | 23677 |
| NCBI Accession: | Q9P0V3.1 |
| UniProt Secondary Accession: | Q9P0V3,O95082, Q309A3, Q53QD0, Q53TD1, |
| UniProt Related Accession: | Q9P0V3 |
| Molecular Weight: | 60,337 Da |
| NCBI Full Name: | SH3 domain-binding protein 4 |
| NCBI Synonym Full Names: | SH3 domain binding protein 4 |
| NCBI Official Symbol: | SH3BP4 |
| NCBI Official Synonym Symbols: | TTP; BOG25 |
| NCBI Protein Information: | SH3 domain-binding protein 4 |
| UniProt Protein Name: | SH3 domain-binding protein 4 |
| UniProt Synonym Protein Names: | EH-binding protein 10; Transferrin receptor-trafficking protein |
| Protein Family: | SH3 domain-binding protein |
| UniProt Gene Name: | SH3BP4 |
| UniProt Entry Name: | SH3B4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SH3BP4 antibody (CAB14351) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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