Anti-RUSC1 Antibody (CAB15417)
- SKU:
- CAB15417
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-RUSC1 Antibody |
| Antibody SKU: | CAB15417 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human RUSC1 (NP_055143.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse brain, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human RUSC1 (NP_055143.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEA QSGT GQLQ EQKK GLLI AVSV SVDK IISH FGAA RNLV QKAQ LGDS RLSP DVGH LVLT TLCP ALHA LVAD GLKP FRKD LITG QRRS SPWS VVEA SVKP GSST RSLG TLYS QVSR LAPL SSSR SRFH AFIL GLLN TKQL ELWF SSLQ EDAG LLSL LYLP TGFF SLAR GGCP SLST ELLL LLQP LSVL TFHL DLLF EHHH HLPL GPPQ APAP PGPP PALQ QTMQ AMLH FGGR LAQS LRGT SKEA ASDP SDSP NLPT PGSW WEQL TQAS RVYA SGGT EGFP LSRW APGR HGTA AEEG AQER PLPT DEMA PGRG LWLG RLFG |
| Gene ID: | 23623 |
| Uniprot: | Q9BVN2 |
| Cellular Location: | Cell junction, Cytoplasm, Cytoplasmic vesicle, Early endosome, Golgi apparatus, Nucleus, cytoskeleton, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 46kDa/52kDa/85kDa/96kDa |
| Observed MW: | 55/100kDa |
| Synonyms: | RUSC1, NESCA |
| Background: |
| UniProt Protein Function: | RUSC1: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: microtubule cytoskeleton; Golgi apparatus; postsynaptic membrane; microtubule; postsynaptic density; cytoplasmic membrane-bound vesicle; early endosome; cytoplasm; cytoplasmic vesicle; cell junction; nucleus Molecular Function:protein binding; SH3/SH2 adaptor activity; actin binding Biological Process: protein polyubiquitination; positive regulation of signal transduction |
| UniProt Code: | Q9BVN2 |
| NCBI GenInfo Identifier: | 157412245 |
| NCBI Gene ID: | 23623 |
| NCBI Accession: | NP_001098673 |
| UniProt Related Accession: | Q9BVN2 |
| Molecular Weight: | 55; 100kDa |
| NCBI Full Name: | RUN and SH3 domain-containing protein 1 isoform a |
| NCBI Synonym Full Names: | RUN and SH3 domain containing 1 |
| NCBI Official Symbol: | RUSC1 |
| NCBI Official Synonym Symbols: | NESCA |
| NCBI Protein Information: | RUN and SH3 domain-containing protein 1 |
| UniProt Protein Name: | RUN and SH3 domain-containing protein 1 |
| UniProt Synonym Protein Names: | New molecule containing SH3 at the carboxy-terminus; Nesca |
| Protein Family: | RUN and SH3 domain-containing protein |
| UniProt Gene Name: | RUSC1 |
| UniProt Entry Name: | RUSC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RUSC1 antibody (CAB15417) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of mouse brain using RUSC1 antibody (CAB15417) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse brain using RUSC1 antibody (CAB15417) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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