Anti-PTN Antibody (CAB3124)
- SKU:
- CAB3124
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PTN Antibody |
| Antibody SKU: | CAB3124 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human PTN |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, Mouse eye, Mouse brain |
| Immunogen: | A synthetic Peptide of human PTN |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5764 |
| Uniprot: | P21246 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 17kDa |
| Synonyms: | PTN, HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1 |
| Background: |
| UniProt Protein Function: | PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q33 Cellular Component: extracellular space; endoplasmic reticulum Molecular Function:heparin binding; growth factor activity; protein phosphatase inhibitor activity Biological Process: nervous system development; positive regulation of cell division; negative regulation of catalytic activity; positive regulation of cell proliferation; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization |
| UniProt Code: | P21246 |
| NCBI GenInfo Identifier: | 131553 |
| NCBI Gene ID: | 5764 |
| NCBI Accession: | P21246.1 |
| UniProt Secondary Accession: | P21246,Q5U0B0, Q6ICQ5, Q9UCC6, |
| UniProt Related Accession: | P21246 |
| Molecular Weight: | 18,942 Da |
| NCBI Full Name: | Pleiotrophin |
| NCBI Synonym Full Names: | pleiotrophin |
| NCBI Official Symbol: | PTN |
| NCBI Official Synonym Symbols: | HARP; HBNF; HBGF8; NEGF1 |
| NCBI Protein Information: | pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) |
| UniProt Protein Name: | Pleiotrophin |
| UniProt Synonym Protein Names: | Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1 |
| Protein Family: | Pleiotrophin |
| UniProt Gene Name: | PTN |
| UniProt Entry Name: | PTN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTN antibody (CAB3124) at 1:400 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded mouse testis using PTN Antibody (CAB3124) at dilution of 1:100 (40x lens). |
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