Anti-PLCL1 Antibody (CAB15302)
- SKU:
- CAB15302
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PLCL1 Antibody |
| Antibody SKU: | CAB15302 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-350 of human PLCL1 (NP_006217.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse heart, Mouse kidney, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-350 of human PLCL1 (NP_006217.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DCIS FMQA GCEL KKVR PNSR IYNR FFTL DTDL QALR WEPS KKDL EKAK LDIS AIKE IRLG KNTE TFRN NGLA DQIC EDCA FSIL HGEN YESL DLVA NSAD VANI WVSG LRYL VSRS KQPL DFME GNQN TPRF MWLK TVFE AADV DGNG IMLE DTSV ELIK QLNP TLKE AKIR LKFK EIQK SKEK LTTR VTEE EFCE AFCE LCTR PEVY FLLV QISK NKEY LDAN DLML FLEA EQGV THIT E |
| Gene ID: | 5334 |
| Uniprot: | Q15111 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 113kDa/122kDa |
| Observed MW: | 140kDa |
| Synonyms: | PLCL1, PLCE, PLCL, PLDL1, PPP1R127, PRIP |
| Background: |
| UniProt Protein Function: | PLCL1: a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors. |
| UniProt Protein Details: | Protein type:Phospholipase Chromosomal Location of Human Ortholog: 2q33 Molecular Function:phospholipase C activity |
| UniProt Code: | Q15111 |
| NCBI GenInfo Identifier: | 226694170 |
| NCBI Gene ID: | 5334 |
| NCBI Accession: | Q15111.3 |
| UniProt Secondary Accession: | Q15111,Q3MJ90, Q53SD3, Q7Z3S3, |
| UniProt Related Accession: | Q15111 |
| Molecular Weight: | 113,012 Da |
| NCBI Full Name: | Inactive phospholipase C-like protein 1 |
| NCBI Synonym Full Names: | phospholipase C like 1 |
| NCBI Official Symbol: | PLCL1 |
| NCBI Official Synonym Symbols: | PLCE; PLCL; PRIP; PLDL1; PPP1R127 |
| NCBI Protein Information: | inactive phospholipase C-like protein 1 |
| UniProt Protein Name: | Inactive phospholipase C-like protein 1 |
| UniProt Synonym Protein Names: | Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP |
| Protein Family: | Inactive phospholipase C-like protein |
| UniProt Gene Name: | PLCL1 |
| UniProt Entry Name: | PLCL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLCL1 antibody (CAB15302) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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