Anti-NOVA1 Antibody (CAB12030)
- SKU:
- CAB12030
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NOVA1 Antibody |
| Antibody SKU: | CAB12030 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 408-507 of human NOVA1 (NP_002506.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, SH-SY5Y |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 408-507 of human NOVA1 (NP_002506.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SAIL GTEK STDG SKDV VEIA VPEN LVGA ILGK GGKT LVEY QELT GARI QISK KGEF VPGT RNRK VTIT GTPA ATQA AQYL ITQR ITYE QGVR AANP QKVG |
| Gene ID: | 4857 |
| Uniprot: | P51513 |
| Cellular Location: | Nucleus |
| Calculated MW: | 19kDa/49kDa/51kDa/52kDa |
| Observed MW: | 60kDa |
| Synonyms: | NOVA1, Nova-1 |
| Background: | This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. |
| UniProt Protein Function: | NOVA1: May regulate RNA splicing or metabolism in a specific subset of developing neurons. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 14q Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:RNA binding Biological Process: locomotory behavior; RNA processing; RNA splicing; synaptic transmission |
| NCBI Summary: | This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51513 |
| NCBI GenInfo Identifier: | 1709303 |
| NCBI Gene ID: | 4857 |
| NCBI Accession: | P51513.1 |
| UniProt Secondary Accession: | P51513,Q6B004, A8K0S4, A8K4Q7, D3DS81, D3DS82, |
| UniProt Related Accession: | P51513 |
| Molecular Weight: | 49,253 Da |
| NCBI Full Name: | RNA-binding protein Nova-1 |
| NCBI Synonym Full Names: | NOVA alternative splicing regulator 1 |
| NCBI Official Symbol: | NOVA1 |
| NCBI Official Synonym Symbols: | Nova-1 |
| NCBI Protein Information: | RNA-binding protein Nova-1 |
| UniProt Protein Name: | RNA-binding protein Nova-1 |
| UniProt Synonym Protein Names: | Neuro-oncological ventral antigen 1; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1 |
| Protein Family: | RNA-binding protein |
| UniProt Gene Name: | NOVA1 |
| UniProt Entry Name: | NOVA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NOVA1 antibody (CAB12030) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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