Anti-NEXN Antibody (CAB13136)
- SKU:
- CAB13136
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NEXN Antibody |
| Antibody SKU: | CAB13136 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 516-675 of human NEXN (NP_653174.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SGC-7901, Mouse testis, Rat brain, Rat spleen, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 516-675 of human NEXN (NP_653174.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RFEQ MAKA REEE EQRR IEEQ KLLR MQFE QREI DAAL QKKR EEEE EEEG SIMN GSTA EDEE QTRS GAPW FKKP LKNT SVVD SEPV RFTV KVTG EPKP EITW WFEG EILQ DGED YQYI ERGE TYCL YLPE TFPE DGGE YMCK AVNN KGSA ASTC ILTI ESKN |
| Gene ID: | 91624 |
| Uniprot: | Q0ZGT2 |
| Cellular Location: | Cell junction, Cytoplasm, Z line, adherens junction, cytoskeleton, myofibril, sarcomere |
| Calculated MW: | 72kDa/73kDa/79kDa/80kDa |
| Observed MW: | 81kDa |
| Synonyms: | NEXN, CMH20, NELIN, nexilin |
| Background: | This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. |
| NCBI Summary: | This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] |
| UniProt Code: | Q0ZGT2 |
| NCBI GenInfo Identifier: | 121945484 |
| NCBI Gene ID: | 91624 |
| NCBI Accession: | Q0ZGT2.1 |
| UniProt Secondary Accession: | Q0ZGT2,Q0D2H2, Q14CC2, Q14CC3, Q16081, Q7Z2X0, Q96DL0 Q9Y2V1, A0PJ84, B4DPZ7, |
| UniProt Related Accession: | Q0ZGT2 |
| Molecular Weight: | 79,362 Da |
| NCBI Full Name: | Nexilin |
| NCBI Synonym Full Names: | nexilin F-actin binding protein |
| NCBI Official Symbol: | NEXN |
| NCBI Official Synonym Symbols: | CMH20; NELIN |
| NCBI Protein Information: | nexilin |
| UniProt Protein Name: | Nexilin |
| UniProt Synonym Protein Names: | F-actin-binding protein; Nelin |
| Protein Family: | Nexilin |
| UniProt Gene Name: | NEXN |
 | Western blot analysis of extracts of various cell lines, using NEXN antibody (CAB13136) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U-2 OS cells using NEXN antibody (CAB13136) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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