Anti-MTUS1 항체 (CAB13437)

Antibody Name:	Anti-MTUS1 Antibody
Antibody SKU:	CAB13437
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:	SH-SY5Y

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NAAH ETSK LEIE ASHS EKLE LLKK AYEA SLSE IKKG HEIE KKSL EDLL SEKQ ESLE KQIN DLKS ENDA LNEK LKSE EQKR RARE KANL KNPQ IMYL EQEL ESLK AVLE IKNE KLHQ QDIK LMKM EKLV DNNT ALVD KLKR FQQE NEEL KARM DKHM AISR QLST EQAV LQES LEKE SKVN KRLS MENE ELLW KLHN GDLC SPKR SPTS SAIP LQSP RNSG SFPS PSIS PR
Gene ID:	57509
Uniprot:	Q9ULD2
Cellular Location:	Cell membrane, Cytoplasm, Golgi apparatus, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:	39kDa/48kDa/50kDa/58kDa/84kDa/135kDa/141kDa
Observed MW:	141KDa

Synonyms:

MTUS1, ATBP, ATIP, ATIP3, ICIS, MP44, MTSG1

Background:

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

UniProt Protein Function:	MTUS1: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Defects in MTUS1 may be a cause of hepatocellular carcinoma (HCC). Belongs to the MTUS1 family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Tumor suppressor; Mitochondrial Chromosomal Location of Human Ortholog: 8p22 Cellular Component: extracellular space
NCBI Summary:	This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9ULD2
NCBI GenInfo Identifier:	158706128
NCBI Gene ID:	57509
NCBI Accession:	Q9ULD2.2
UniProt Secondary Accession:	Q9ULD2,Q63HJ6, Q659F4, Q6PK49, Q6URW7, Q8N4M6, A8K135 B2RBJ6, B3KWJ9, B4DH03, B9EGA1, D3DSP8,
UniProt Related Accession:	Q9ULD2
Molecular Weight:	48,050 Da
NCBI Full Name:	Microtubule-associated tumor suppressor 1
NCBI Synonym Full Names:	microtubule associated tumor suppressor 1
NCBI Official Symbol:	MTUS1
NCBI Official Synonym Symbols:	ATBP; ATIP; ICIS; MP44; MTSG1
NCBI Protein Information:	microtubule-associated tumor suppressor 1
UniProt Protein Name:	Microtubule-associated tumor suppressor 1
UniProt Synonym Protein Names:	AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Mitochondrial tumor suppressor 1
Protein Family:	Microtubule-associated tumor suppressor
UniProt Gene Name:	MTUS1
UniProt Entry Name:	MTUS1_HUMAN

	Western blot analysis of extracts of SH-SY5Y cells, using MTUS1 antibody (CAB13437) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
	Immunofluorescence analysis of A549 cells using MTUS1 antibody (CAB13437). Blue: DAPI for nuclear staining.

Antibodies

Anti-MTUS1 Antibody (CAB7601)

MTUS1 Antibody (PACO10654)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)