Anti-MCOLN2 Antibody (CAB18560)
- SKU:
- CAB18560
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-MCOLN2 Antibody |
| Antibody SKU: | CAB18560 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MCOLN2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | THP-1, SKOV3 |
| Immunogen: | Recombinant protein of human MCOLN2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 255231 |
| Uniprot: | Q8IZK6 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 75kDa |
 | Western blot - MCOLN2 Rabbit pAb (CAB18560) |
| Synonyms: | TRP-ML2, TRPML2, MCOLN2 |
| Background: |
| UniProt Protein Function: | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). |
| NCBI Summary: | Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009] |
| UniProt Code: | Q8IZK6 |
| NCBI GenInfo Identifier: | 54792073 |
| NCBI Gene ID: | 255231 |
| NCBI Accession: | NP_694991.2 |
| UniProt Secondary Accession: | Q8IZK6,Q2M3I6, Q5TAG5, Q8N9R3, A6NI99, |
| UniProt Related Accession: | Q8IZK6 |
| Molecular Weight: | 62,685 Da |
| NCBI Full Name: | mucolipin-2 isoform 1 |
| NCBI Synonym Full Names: | mucolipin 2 |
| NCBI Official Symbol: | MCOLN2 |
| NCBI Official Synonym Symbols: | TRPML2; TRP-ML2 |
| NCBI Protein Information: | mucolipin-2 |
| UniProt Protein Name: | Mucolipin-2 |
| UniProt Synonym Protein Names: | Transient receptor potential channel mucolipin 2; TRPML2 |
| Protein Family: | Mucolipin |
| UniProt Gene Name: | MCOLN2 |
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