Anti-KIRREL2 Antibody (CAB13130)
- SKU:
- CAB13130
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-KIRREL2 Antibody |
| Antibody SKU: | CAB13130 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human KIRREL2 (NP_954649.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human KIRREL2 (NP_954649.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPSP HFLQ QPED LVVL LGEE ARLP CALG AYWG LVQW TKSG LALG GQRD LPGW SRYW ISGN AANG QHDL HIRP VELE DEAS YECQ ATQA GLRS RPAQ LHVL VPPE APQV LGGP SVSL VAGV PANL TCRS RGDA RPTP ELLW FRDG VLLD GATF HQTL LKEG TPGS VEST LTLT PFSH DDGA TFVC RARS QALP TGRD TAIT |
| Gene ID: | 84063 |
| Uniprot: | Q6UWL6 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 23kDa/61kDa/67kDa/75kDa |
| Observed MW: | 95kDa |
| Synonyms: | KIRREL2, FILTRIN, NEPH3, NLG1 |
| Background: | This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. |
| UniProt Protein Function: | KIRREL2: Belongs to the immunoglobulin superfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: plasma membrane Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q6UWL6 |
| NCBI GenInfo Identifier: | 308153459 |
| NCBI Gene ID: | 84063 |
| NCBI Accession: | Q6UWL6.2 |
| UniProt Secondary Accession: | Q6UWL6,Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1, C9JHF1 C9JJ76, F1T0I2, |
| UniProt Related Accession: | Q6UWL6 |
| Molecular Weight: | 23,583 Da |
| NCBI Full Name: | Kin of IRRE-like protein 2 |
| NCBI Synonym Full Names: | kin of IRRE like 2 (Drosophila) |
| NCBI Official Symbol: | KIRREL2 |
| NCBI Official Synonym Symbols: | NLG1; NEPH3; FILTRIN |
| NCBI Protein Information: | kin of IRRE-like protein 2 |
| UniProt Protein Name: | Kin of IRRE-like protein 2 |
| UniProt Synonym Protein Names: | Kin of irregular chiasm-like protein 2; Nephrin-like protein 3 |
| Protein Family: | Kin of IRRE-like protein |
| UniProt Gene Name: | KIRREL2 |
| UniProt Entry Name: | KIRR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KIRREL2 antibody (CAB13130) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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