Anti-ITGA3 Antibody (CAB17502)
- SKU:
- CAB17502
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-ITGA3 Antibody |
| Antibody SKU: | CAB17502 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein of Human ITGA3. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse lung, Rat lung, A-431, PC-3, A-549 |
| Immunogen: | Recombinant fusion protein of Human ITGA3. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3675 |
| Uniprot: | P26006 |
| Cellular Location: | |
| Calculated MW: | 116kDa/118kDa |
| Observed MW: | 125kDa/130kDa |
 | Western blot - ITGA3 Polyclonal Antibody (CAB17502) |
| Synonyms: | CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, ITGA3 |
| Background: | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015] |
| UniProt Protein Function: | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. |
| NCBI Summary: | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P26006 |
| NCBI GenInfo Identifier: | 347595830 |
| NCBI Gene ID: | 3675 |
| NCBI Accession: | P26006.5 |
| UniProt Secondary Accession: | P26006,A7E246, B7ZM80, B9EGQ1, D3DTX4, D3DTX5, |
| UniProt Related Accession: | P26006 |
| Molecular Weight: | |
| NCBI Full Name: | Integrin alpha-3 |
| NCBI Synonym Full Names: | integrin subunit alpha 3 |
| NCBI Official Symbol: | ITGA3 |
| NCBI Official Synonym Symbols: | VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3 |
| NCBI Protein Information: | integrin alpha-3 |
| UniProt Protein Name: | Integrin alpha-3 |
| UniProt Synonym Protein Names: | CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA3 |
| UniProt Entry Name: | ITA3_HUMAN |
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