Anti-INTS4 Antibody (CAB6339)
- SKU:
- CAB6339
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-INTS4 Antibody |
| Antibody SKU: | CAB6339 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human INTS4 (NP_291025.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, HepG2, Jurkat, A-549, Mouse testis, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human INTS4 (NP_291025.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAH LKKR VYEE FTKV VQPQ EEIA TKKL RLTK PSKS AALH IDLC KATS PADA LQYL LQFA RKPV EAES VEGV VRIL LEHY YKEN DPSV RLKI ASLL GLLS KTAG FSPD CIMD DAIN ILQN EKSH QVLA QLLD TLLA IGTK LPEN QAIQ MRLV DVAC KHLT DTSH GVRN KCLQ LLGN LGSL EKSV TKDA EGLA ARDV QKII GDYF SDQD PRVR TAAI KAML QLHE RGLK LHQT IYNQ ACKL LSDD YEQV RSAA VQLI WVVS QLYP ESIV PI |
| Gene ID: | 92105 |
| Uniprot: | Q96HW7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 38kDa/56kDa/57kDa/108kDa |
| Observed MW: | 108kDa |
| Synonyms: | INTS4, INT4, MST093 |
| Background: |
| UniProt Protein Function: | INT4: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 4 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: integrator complex Molecular Function:protein binding Biological Process: snRNA processing |
| NCBI Summary: | INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96HW7 |
| NCBI GenInfo Identifier: | 118572560 |
| NCBI Gene ID: | 92105 |
| NCBI Accession: | Q96HW7.2 |
| UniProt Secondary Accession: | Q96HW7,Q2YD62, Q6PJG4, Q7Z4E7, Q96G32, Q96GA1, Q9BRC0 |
| UniProt Related Accession: | Q96HW7 |
| Molecular Weight: | 38,117 Da |
| NCBI Full Name: | Integrator complex subunit 4 |
| NCBI Synonym Full Names: | integrator complex subunit 4 |
| NCBI Official Symbol: | INTS4 |
| NCBI Official Synonym Symbols: | INT4; MST093 |
| NCBI Protein Information: | integrator complex subunit 4; MSTP093 |
| UniProt Protein Name: | Integrator complex subunit 4 |
| Protein Family: | Integrator complex |
| UniProt Gene Name: | INTS4 |
| UniProt Entry Name: | INT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INTS4 antibody (CAB6339) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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