Anti-FHL5 Antibody (CAB15756)
- SKU:
- CAB15756
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-FHL5 Antibody |
| Antibody SKU: | CAB15756 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-284 of human FHL5 (NP_065228.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-284 of human FHL5 (NP_065228.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTTA HFYC QYCT ASLL GKKY VLKD DSPY CVTC YDRV FSNY CEEC KKPI ESDS KDLC YKDR HWHE GCFK CTKC NHSL VEKP FAAK DERL LCTE CYSN ECSS KCFH CKRT IMPG SRKM EFKG NYWH ETCF VCEN CRQP IGTK PLIS KESG NYCV PCFE KEFA HYCN FCKK VITS GGIT FCDQ LWHK ECFL CSGC RKDL CEEQ FMSR DDYP FCVD CYNH LYAN KCVA CSKP ISGL TGAK FICF QDSQ WHSE CFNC GKCS VSLV GKGF LTQN KEIF CQKC GSGM DTDI |
| Gene ID: | 9457 |
| Uniprot: | Q5TD97 |
| Cellular Location: | Nucleus |
| Calculated MW: | 32kDa |
| Observed MW: | 35kDa |
| Synonyms: | FHL5, 1700027G07Rik, ACT, FHL-5, dJ393D12.2 |
| Background: | The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | FHL5: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q16.1-q16.3 Cellular Component: nucleus Molecular Function:protein binding; zinc ion binding; transcription coactivator activity Biological Process: positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q5TD97 |
| NCBI GenInfo Identifier: | 282847459 |
| NCBI Gene ID: | 9457 |
| NCBI Accession: | NP_001164278.1 |
| UniProt Secondary Accession: | Q5TD97,Q5TD98, Q8WW21, Q9NQU2, B2RBD1, E1P526, |
| UniProt Related Accession: | Q5TD97 |
| Molecular Weight: | 32,720 Da |
| NCBI Full Name: | four and a half LIM domains protein 5 |
| NCBI Synonym Full Names: | four and a half LIM domains 5 |
| NCBI Official Symbol: | FHL5 |
| NCBI Official Synonym Symbols: | ACT; dJ393D12.2 |
| NCBI Protein Information: | four and a half LIM domains protein 5 |
| UniProt Protein Name: | Four and a half LIM domains protein 5 |
| UniProt Synonym Protein Names: | Activator of cAMP-responsive element modulator in testis; Activator of CREM in testis |
| Protein Family: | Four and a half LIM domains protein |
| UniProt Gene Name: | FHL5 |
| UniProt Entry Name: | FHL5_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using FHL5 antibody (CAB15756) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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