| UniProt Protein Function: | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
| UniProt Code: | O00303 |
| NCBI GenInfo Identifier: | 4503519 |
| NCBI Gene ID: | 8665 |
| NCBI Accession: | NP_003745.1 |
| UniProt Secondary Accession: | O00303,Q6IB45, Q8N978, A8K0S2, |
| UniProt Related Accession: | O00303 |
| Molecular Weight: | 38 KD |
| NCBI Full Name: | eukaryotic translation initiation factor 3 subunit F |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 3 subunit F |
| NCBI Official Symbol: | EIF3F |
| NCBI Official Synonym Symbols: | EIF3S5; eIF3-p47 |
| NCBI Protein Information: | eukaryotic translation initiation factor 3 subunit F |
| UniProt Protein Name: | Eukaryotic translation initiation factor 3 subunit F |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme eIF3f (EC:3.4.19.12); Eukaryotic translation initiation factor 3 subunit 5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03005; eIF-3-epsilonUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03005; eIF3 p47UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03005 |
| UniProt Gene Name: | EIF3F |
