Anti-CYP2C18 Antibody (CAB7431)
- SKU:
- CAB7431
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CYP2C18 Antibody |
| Antibody SKU: | CAB7431 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NKIA ENFA YIKS YVLE RIKE HQES LDMN SARD FIDC FLIK MEQE KHNQ QSEF TVES LIAT VTDM FGAG TETT STTL RYGL LLLL KYPE VTAK VQEE IECV VGRN RSPC MQDR SHMP YTDA VVHE IQRY IDLL PTNL PHAV TCDV KFKN YLIP KGTT IITS LTSV LHND KEFP NPEM FDPG HFLD KSGN FKKS DYFM PFSA GKRM CMGE GLAR MELF LFLT TILQ NFNL KSQV DPKD IDIT PIAN AFGR VPPL YQLC FIPV |
| Gene ID: | 1562 |
| Uniprot: | P33260 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 48kDa/55kDa |
| Observed MW: | 50kDa |
| Synonyms: | CYP2C18, CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17 |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CYP2C18: a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Participates in the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid Chromosomal Location of Human Ortholog: 10q24 Cellular Component: endoplasmic reticulum membrane Molecular Function:arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding; steroid hydroxylase activity Biological Process: epoxygenase P450 pathway; xenobiotic metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33260 |
| NCBI GenInfo Identifier: | 67476954 |
| NCBI Gene ID: | 1562 |
| NCBI Accession: | P33260.3 |
| UniProt Secondary Accession: | P33260,Q16703, Q16751, Q4VAT5, Q6GRG1, B2R8K2, |
| UniProt Related Accession: | P33260 |
| Molecular Weight: | 48,805 Da |
| NCBI Full Name: | Cytochrome P450 2C18 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily C member 18 |
| NCBI Official Symbol: | CYP2C18 |
| NCBI Official Synonym Symbols: | CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C |
| NCBI Protein Information: | cytochrome P450 2C18 |
| UniProt Protein Name: | Cytochrome P450 2C18 |
| UniProt Synonym Protein Names: | CYPIIC18; Cytochrome P450-6b/29c |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2C18 |
| UniProt Entry Name: | CP2CI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYP2C18 antibody (CAB7431) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using CYP2C18 antibody (CAB7431) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using CYP2C18 antibody (CAB7431) at dilution of 1:100 (40x lens). |
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