Anti-CDC37 Antibody (CAB2859)
- SKU:
- CAB2859
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CDC37 Antibody |
| Antibody SKU: | CAB2859 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CDC37 (NP_008996.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:200 - 1:1000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HeLa, HepG2, BT474, HT-1080 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CDC37 (NP_008996.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVDY SVWD HIEV SDDE DETH PNID TASL FRWR HQAR VERM EQFQ KEKE ELDR GCRE CKRK VAEC QRKL KELE VAEG GKAE LERL QAEA QQLR KEER SWEQ KLEE MRKK EKSM PWNV DTLS KDGF SKSM VNTK PEKT EEDS EEVR EQKH KTFV EKYE KQIK |
| Gene ID: | 11140 |
| Uniprot: | Q16543 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | 50kDa |
| Synonyms: | CDC37, P50CDC37 |
| Background: | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. |
| UniProt Protein Function: | CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: protein complex; cytoplasm; cytosol Molecular Function:protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding Biological Process: protein folding; protein stabilization; regulation of cyclin-dependent protein kinase activity; protein targeting |
| NCBI Summary: | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16543 |
| NCBI GenInfo Identifier: | 21542000 |
| NCBI Gene ID: | 11140 |
| NCBI Accession: | Q16543.1 |
| UniProt Secondary Accession: | Q16543,Q53YA2, |
| UniProt Related Accession: | Q16543 |
| Molecular Weight: | 378 |
| NCBI Full Name: | Hsp90 co-chaperone Cdc37 |
| NCBI Synonym Full Names: | cell division cycle 37 |
| NCBI Official Symbol: | CDC37 |
| NCBI Official Synonym Symbols: | P50CDC37 |
| NCBI Protein Information: | hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog) |
| UniProt Protein Name: | Hsp90 co-chaperone Cdc37 |
| UniProt Synonym Protein Names: | Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Hsp90 co-chaperone Cdc37, N-terminally processed |
| Protein Family: | Hsp90 co-chaperone |
| UniProt Gene Name: | CDC37 |
| UniProt Entry Name: | CDC37_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDC37 antibody (CAB2859) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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