IL36RN Antibody (PACO40694)
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주문- SKU:
- PACO40694
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | IL36RN Antibody (PACO40694) |
Antibody SKU: | PACO40694 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Interleukin-36 receptor antagonist protein (1-155AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: IL36RN antibody at 16µg/ml + Mouse stomach tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 17 kDa. Observed band size: 17 kDa. | |
Western Blot. Positive WB detected in: Rat kidney tissue. All lanes: IL36RN antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 17 kDa. Observed band size: 17 kDa. |
Background: | Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 α (IL-1A), β (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. |
Synonyms: | Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1), IL36RN, FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 |
UniProt Protein Function: | IL1F5: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response. Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP). PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. Belongs to the IL-1 family. |
UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 2q14 Cellular Component: extracellular space Molecular Function:cytokine activity; interleukin-1 receptor binding; protein binding Biological Process: antifungal humoral response; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of interleukin-17 production Disease: Psoriasis 14, Pustular |
NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBH0 |
NCBI GenInfo Identifier: | 25008600 |
NCBI Gene ID: | 26525 |
NCBI Accession: | Q9UBH0.1 |
UniProt Secondary Accession: | Q9UBH0,Q56AT9, Q7RTZ6, A8K2I4, |
UniProt Related Accession: | Q9UBH0 |
Molecular Weight: | 16,962 Da |
NCBI Full Name: | Interleukin-36 receptor antagonist protein |
NCBI Synonym Full Names: | interleukin 36 receptor antagonist |
NCBI Official Symbol: | IL36RN |
NCBI Official Synonym Symbols: | FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA) |
NCBI Protein Information: | interleukin-36 receptor antagonist protein |
UniProt Protein Name: | Interleukin-36 receptor antagonist protein |
UniProt Synonym Protein Names: | FIL1 delta; IL-1-related protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; Interleukin-1-like protein 1; IL-1L1 |
Protein Family: | Interleukin-36 receptor antagonist protein |
UniProt Gene Name: | IL36RN |
UniProt Entry Name: | I36RA_HUMAN |
Antibodies |
Anti-IL36RN Antibody (CAB8205) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |