Human MICA Recombinant Protein (RPES4614)

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SKU:
RPES4614
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human MICA Recombinant Protein

MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.

Product Name:Human MICA Recombinant Protein (RPES4614)
Product Code:RPES4614
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1
Accession:Q29983
Sequence:Ala23-Glu308
Fusion tag:C-Fc
Activity:Immobilized Human MICA-Fc at 2µg/ml(100 ?l/well) can bind Human NKG2DL2-His(Cat: PKSH032816). The ED50 of Human MICA-Fc is 2.29 ug/ml .
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human MHC Class I Polypeptide-Related Sequence A is produced by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:59.9 kDa
AP Mol Mass:88 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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system_update_alt데이터시트Human MICA Recombinant Protein MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical
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